Detection of early-formed, antigen-specific clones in SARS-CoV-2-reactive B cells after longitudinal analysis Antigen SARSCoV2 Coronavirus Disease COVID JCI_Insight
By Dr. Priyom Bose, Ph.D.Nov 30 2022Reviewed by Aimee Molineux This is mainly because of the continual emergence of new SARS-CoV-2 variants, such as the Omicron and Delta strains, which can escape immune responses induced via vaccination and natural infection.
The emergence of SARS-CoV-2 variants has drawn more attention to the study of memory B cells . Animal model studies on influenza indicated that the MBC pool possesses a greater breadth of antigenic binding than the plasmablast response. This finding implies that plasma cells and serum Abs protect against reinfection with the same viral strain, while the MBC pool can protect against a diverse range of emerging variants.
About the Study A recent JCI Insight study addressed this gap in research and utilized a longitudinal approach to provide important insights into the evolution of B cells after viral infections. This study recruited six severe/critically infected SARS-CoV-2 patients post-hospital admission at Sahlgrenska University Hospital, Sweden. They were followed through the disease progression and recovery period for up to one year.
Study Findings The longitudinal study design enabled scientists to trace the origin of antigen-specific B cells and understand their evolution pattern in each patient. A significant change in the circulating immune populations was observed during the infection. During the early phase of hospitalization, CD4 T cells with strong IFN signatures were detected, which disappeared within 3 months.
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