Study maps alterations that make melanoma more severe, could lead to better therapies and diagnosis NatureComms
Furthermore, the DNA methylation profile of acral melanomas is barely characterized, which could be due in part to its scarcity. It is also unclear whether molecular differences between UV-related and non UV-related melanoma types are due to intrinsic pathological characteristics, extrinsic responses to UV exposure or a combination of both.
This is followed by functional genomic, pathway and methylation-expression analysis of the identified DNA methylation alterations, assessment of their cancer driver roles using a multi-OMICs approach, investigation of their effect on patient survival, and validation of the top hits using bisulfite pyrosequencing.
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