'COVID rebound' is common, even in untreated patients, reports study
The uptake of nirmatrelvir plus ritonavir in patients with COVID-19 has been limited by concerns around the rebound phenomenon despite the scarcity of evidence around its epidemiology. The purpose of this study was to prospectively compare the epidemiology of rebound in NPR-treated and untreated participants with acute COVID-19 infection.
Viral rebound based on test results and COVID-19 symptom rebound based on patient-reported symptoms were evaluated.Viral rebound incidence was 14.2% in the NPR treatment group and 9.3% in the control group . Symptom rebound incidence was higher in the treatment group compared to controls . There were no notable differences in viral rebound by age, gender, pre-existing conditions, or major symptom groups during the acute phase or at the 1-month interval.
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