Bivalent boosters tested against all SARS-CoV-2 Omicron lineages Omicron SARSCoV2 omicron Coronavirus Disease COVID Bivalent Boosters biorxivpreprint CDCgov JohnsHopkins wfubmc BIDMChealth VUMChealth
Early SARS-CoV-2 Omicron lineage variants have mutated, resulting in divergent lineages that drove the 2022 coronavirus disease 2019 pandemic. As a result, the U.S. Food and Drug Administration authorized bivalent mRNA vaccines designed to widen protection against current and future variants in August 2022, and the U.S. Centers for Disease Control and Prevention recommended their use in September 2022.
The team obtained serum samples from vaccine recipients two to six weeks after being vaccinated with the third dose or two to seven weeks after vaccination with the fourth dosage of a bivalent booster mRNA vaccine.
Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The sera from the third dosage exhibited significant neutralizing activity in response to the 614D reference virus, moderate activity in response to the BA.1, BA.2, BA.5, and BA.2.75 strains, and poor activity against the BA.2.75.2, BQ.1, BQ.1.1, BN.1, XBB, and XBB.1 strains. Compared to the 614D nAb titers, the BA.1, BA.5, BA.2, and BA.2.
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