Real-world effectiveness of the bivalent vaccine for preventing COVID-19 hospitalizations in non-hospitalized subjects covid coronavirus covid hospital vaccine vaccination
By Dr. Chinta SidharthanJan 11 2023Reviewed by Danielle Ellis, B.Sc. In a recent study posted to Preprints with the Lancet*, researchers investigated the efficacy of a booster dose of the bivalent messenger ribonucleic acid coronavirus disease 2019 vaccine in preventing severe outcomes during severe acute respiratory syndrome coronavirus 2 infections.
Recently developed bivalent mRNA vaccines contain mRNA sequences that code for components of the ancestral SARS-CoV-2 strain and one of the more recent Omicron subvariants, such as the BA.4/BA.5. About the study In the present study, the researchers performed a retrospective cohort-based analysis of medical health records obtained from Clalit Health Services, which includes medical data on close to two-thirds of Israel’s population above the age of 65. The participants had been offered the Pfizer-BioNTech bivalent mRNA vaccine and were followed up for at least two weeks after vaccination.
The association between severe COVID-19 outcomes and booster doses of the bivalent vaccine was analyzed using a Cox proportional-hazards regression model while adjusting for comorbidities and demographic factors. Despite the effectiveness of the bivalent vaccine, its uptake as a booster dose was markedly low, with less than 14% of the eligible population availing of the vaccine. The authors believe that the low uptake rate could be due to misconceptions about the vaccine, such as side effects or misinformation that previous vaccine doses or SARS-CoV-2 infections are sufficient in protecting against future infections.
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