Association of COVID-19 severity with nasopharyngeal fungal colonization and interleukin-17 induction medrxivpreprint MIT UMMCnews BostonChildrens NIAIDNews COVID19 coronavirus covid fungi infection immunity
By Pooja Toshniwal PahariaOct 28 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers evaluated the concurrent colonization of fungi in the nasopharynx of severe coronavirus disease 2019 patients. They explored antifungal immunity pathways by analyzing data from their previous study comprising patients with acute SARS-CoV-2 infections.
About the study In the present cross-sectional study, researchers characterized the clinical characteristics of 56 previous study participants and identified those with severe SARS-CoV-2 infections and concomitant Candida species-derived transcript detection within URT [tracheal and nasopharyngeal ] samples.
Patients were clinically evaluated for fungal infections among three COVID-19 patients with high Candida spp. abundance, as identified previously by meta-transcriptomics. Further, the team investigated whether the nasal tissues of such individuals showed reactive or aberrant or reactive IL-17 expression. The expression of interleukins - 1β, 4, and 17A, and IFN-α, g genes was evaluated. Nasal epithelial cells were examined for transcriptomic signatures consistent with the cytokine levels.
Candida spp. reads were only detected among severe COVID-19 patients with mechanical ventilation and intubation requirements. RNA-seq results correlated generally with those of ETA aspirates. The findings indicated a significant clinical concern for hospitalized severe COVID-19 patients for Candida infection testing. 28-day death rates among COVID-19 patients were comparable between Candida spp. positive vs. negative individuals.
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