Antibody response trajectories among solid organ transplant recipients in association with mycophenolate mofetil administration Antibody SARSCoV2 COVID19
By Pooja Toshniwal PahariaOct 11 2022Reviewed by Aimee Molineux In a recent study published in Transplantation Proceedings, researchers explored the trajectory of antibody titers after coronavirus disease 2019 vaccination among solid organ transplant recipients with or without mycophenolate mofetil , or withdrawn from MMF.
The study comprised 78 SOTs on immunosuppressive medications who received two doses of Pfizer-BioNTech’s BNT162b2 messenger ribonucleic acid COVID-19 vaccine and was conducted between 1 July 2021 and 30 April 2022. The team excluded individuals with prior PCR -confirmed COVID-19 history or anti-SARS-CoV-2 nucleocapsid protein Abs prior to the second COVID-19 vaccination.
The team explored the association between MMF concentration immediately prior to the second vaccination and anti-S RBD IgG titers at the first outpatient visit after the second COVID-19 vaccination. They also comprehensively analyzed B lymphocyte and the cluster of differentiation 4+ helper and CD8+ cytotoxic T lymphocyte counts before and after MMF withdrawal.
Low seroconversion rates and low Ab titers were observed among MMF-treated SOTs. An inverse linear relationship between neutralizing Ab titers and MMF concentration was observed. MMF administration significantly modified Ab response trajectories, and post MMF withdrawal, significantly elevated B-lymphocyte counts with improved Ab titers were observed. However, no significant differences were observed in CD4+, and CD8+ T-lymphocyte counts prior to and post-MMF withdrawal.
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