A new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.
Reviewed by Lily Ramsey, LLMAug 31 2023 That is an innovation now presented by researchers at the University of Gothenburg, together with colleagues at University of Lund and in Montreal, Canada.
However, even if promising, a concern has been that classifying early patients into either having "AD or not AD" will still result in a rather high percentage of false positives and false negatives . The workflow was evaluated in 348 MCI participants from the Swedish BioFINDER studies and validated in the independent TRIAD cohort also using an independent method for analysis of plasma p-tau217.
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New blood test gives high accuracy screen for Alzheimer's diseaseA new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology. That is an innovation now presented by researchers at the University of Gothenburg, together with colleagues at University of Lund and in Montreal, Canada.
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Scientists reverse Alzheimer's plaque formation in animal models by boosting activity of key ion channelLosing the activity of a key ion channel in the brain may contribute to the buildup of a devastating and toxic protein responsible for the clumps of plaque that accumulate in Alzheimer's disease, a team of neurobiologists in China has found.
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Discoveries on memory mechanisms could unlock new therapies for Alzheimer's and other brain diseasesScientists at the University of Colorado Anschutz Medical Campus have made a 'paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome. The study was published in the journal Nature.
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New study finds genetic factor fends off Alzheimer's and Parkinson'sAbout one in every five people carries a version of a gene that—although largely unsung—appears to confer protection against both Alzheimer's disease and Parkinson's disease, Stanford Medicine investigators and their colleagues have learned. These lucky people may someday benefit all the more from a vaccine that could slow or stall the progression of these two most common neurodegenerative conditions.
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Educational attainment found to protect against a genetic risk factor for Alzheimer's diseaseA new study by researchers from Mass General Brigham further illustrates that when it comes to risk of Alzheimer's disease, even genetically determined forms of the disease, genetics is only one piece of the puzzle.
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Gene variant protects against Alzheimer's and Parkinson's diseasesAbout one in every five people carries a version of a gene that, although largely unsung, appears to confer protection against both Alzheimer's disease and Parkinson's disease, Stanford Medicine investigators and their colleagues have learned.
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