Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered a type of gut bacteria that might help improve insulin resistance, and thus protect against the development of obesity and type-2 diabetes.
Reviewed by Megan Craig, M.Sc.Aug 31 2023 The study, published August 30 in the scientific journal Nature, involved genetic and metabolic analysis of human fecal microbiomes and then corroborating experiments in obese mice.
Our guts contain trillions of bacteria, many of which break down the carbohydrates that we eat when they would otherwise remain undigested. While many have proposed that this phenomenon is related to obesity and pre-diabetes, the facts remain unclear because there are so many different bacteria and there is a lack of metabolic data.
We found that higher insulin resistance was associated with excessive carbohydrates in the fecal matter, especially monosaccharides like glucose, fructose, galactose, and mannose." Next, they characterized the gut microbiota of the study participants and their relationship with insulin resistance and fecal carbohydrates. The guts of people with higher insulin resistance contained more bacteria from the taxonomic order c than from other orders.
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