Currently, it is a difficult and laborious process to place two cells in contact with each other to examine their binding characteristics. It is however a necessary step in understanding how cells interact in the hopes of finding novel cancer treatments, especially cell-based cancer immunotherapies.
with fluids and other cells, the cell or cells need to be trapped, or held in a specific place. For T cell screening in such a device, researchers would need to trap both the T cell and the tumor cell without damaging the cell—a feat that was not yet possible and has previously excluded T cell screening from the advantages of lab-on-a-chip technology.
The novelty of Lipp's device is that it brings T cell screening into the microfluidics world by combining two trapping methods: one based on planar hydrodynamic trapping of cells and another on dielectrophoretic trapping. These hydrodynamic traps rely on microscopic holes that trap the cell through changes in pressure within the liquid environment—think of gently sucking up a baseball with a vacuum hose to hold it in place, but thousands of times smaller. Whereas DEP trapping involves an entirely different technology that takes advantage of a cell's polarity to electrically trap it by turning on and off electrodes.
The combination of these two distinct trapping systems enables the independent manipulation of cells in theAs a result, different adhesion assays can be performed on the chip, making it a versatile tool for various immunological studies. The new microfluidic chip is designed to preserve cell integrity and receptor functions, paving the way for the development of larger throughput devices through automation.
Combining this technology with automation should lead to faster and more cost-effective T cell screening and sorting, making cell-based immunotherapies more accessible and widely applicable.Clémentine Lipp et al, Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays,
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