What is the association between obesity and insulin resistance in youth and its production of colon-derived acetate, gut-derived hormone secretion, and adipose tissue lipolysis? JAMANetworkOpen obesity insulinresistance insulin youth adipose
By Dr. Chinta SidharthanMay 11 2023Reviewed by Lily Ramsey, LLM In a recent study published in the JAMA Network Open Journal, researchers assessed whether insulin resistance and adiposity in youth were linked to the fermentation of dietary fibers in the colon, secretion of gut-derived hormones, rate of production of acetate, and adipose tissue lipolysis.
The intake of dietary fibers and other indigestible carbohydrates is recommended to reduce adiposity and improve metabolic conditions in individuals with obesity, and the beneficial effects are thought to be exerted through colonic fermentation. Specifically, they examined how the effect of colonic fermentation on enteroendocrine secretion, insulin clearance, and lipolysis of adipose tissue could be associated with insulin resistance and adiposity.
The primary outcomes were the response of ghrelin, PYY, active GLP-1, and free fatty acids to the colonic fermentation of lactulose. Results The results reported that though the extent of colonic fermentation after the ingestion of lactulose was comparable in lean, OIS, and OIR groups, the rate of acetate increase was lower in the OIR youth than the ones in the other two groups.
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