In February 2021, The Conversation reported on a trial for a new weight-loss drug, called semaglutide, that was being hailed in the media as a 'gamechanger.' Gamechanger is a word used far too often by journalists to describe things that are, frankly, mundane. This time, though, the word seems apt.
In February 2021, The Conversation reported on a trial for a new weight-loss drug, called semaglutide, that was being hailed in the media as a"gamechanger." Gamechanger is a word used far too often by journalists to describe things that are, frankly, mundane. This time, though, the word seems apt.
In the past two and a half years, a lot of ink has been spilt discussing the merits and demerits of this drug—better known by its brand names Ozempic and Wegovy—including in The Conversation. We start right at the very beginning, with a brutish-looking lizard, found in North American deserts, called the Gila monster. This reptile's venom—which causes excruciating and long-lasting pain—was the inspiration for the drug.
One of the compounds in the venom is similar to an appetite-suppressing hormone found in humans called GLP-1. Simon Cork, a senior lecturer in physiology, provides an excellent explanation of how the drug works. Semaglutide was initially developed as a treatment for type 2 diabetes. The drug, developed by Novo Nordisk, is sold as Ozempic. Reports soon emerged of a curious side-effect in people prescribed the drug: dramatic and sustained weight loss. Studies soon confirmed these reports and a different formulation of the drug, called Wegovy, was developed for weight loss. It is a once-a-week jab.
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