Utilizing marine sources to extract DHA to treat Alzheimer’s Aging AlphaLinolenicAcid Alzheimer Antioxidant DHA Marine_Drugs ULisboa_ plasticseapt UPorto
By Nidhi Saha, BDSNov 15 2022Reviewed by Benedette Cuffari, M.Sc. A recent Marine Drugs journal study discusses the anti-neurodegenerative effects of docosahexaenoic acid and DHA-rich phospholipids derived from fisheries and aquaculture byproducts, with a particular focus on how these components may assist in the treatment of Alzheimer's disease .
DHA has a vital role in supporting the development of the brain and eyes in newborns, as well as preventing preterm delivery, tumors, some malignancies, inflammatory processes, and cardiovascular disease. The cardioprotective properties of DHA are attributed to its ability to alter lipid metabolism, vascular function, and membrane dynamics, as well as its anti-inflammatory and antioxidant effects.
What is AD? AD is a progressive, irreversible, and complicated disease. Around 50 million people worldwide suffer from dementia, with AD accounting for 50-75% of these cases. β-amyloid plaques, for example, can interfere with inter-neuronal communication at synapses, thereby contributing to neurodegeneration that can lead to neuronal damage or death.
Appropriate high-density lipoprotein cholesterol levels optimize neurological function and are essential for synapse maintenance. Meanwhile, high cholesterol levels can increase the risk for AD. The N-methyl-D-aspartate receptor antagonist protects against neurotoxicity by preventing the consequences of high glutamate levels. Memantine, a partial NMDA receptor antagonist, and its combination with donepezil, has been approved for the treatment of moderate-to-severe AD by the United States Food and Drug Administration .
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