Chemotherapy is one of the main therapeutic modalities for cancer patients. Chemotherapeutic drugs destroy cancer cells in the body, but patients frequently face side effects since the drugs do not selectively target cancer cells and may also be toxic to healthy cells to varying extents.
One example is the chemotherapeutic drug called doxorubicin , which is frequently given to cancer patients with breast cancer and certain types of blood cancers. However, up to one third of patients receiving high-dose doxorubicin treatment experience heart damage, which in the long term can lead to. Like cancer cells, dox can enter normal heart cells where it damages the cell's DNA and ultimately causes cell death.
To increase dox's specificity for cancer cells, researchers Arun Sharma, Xiaojiang Cui, and colleagues at Cedars-Sinai Medical Center and scientists at Sunstate Biosciences Inc, U.S., came up with a way of enveloping dox with a protein shell. The findings are published in the journalThe new formulation called SPEDOX-6 increased the drug's likelihood of being taken up by fast-dividing cells such as cancer cells while also reducing its toxicity to heart cells.
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