The Ultrasound and Elasticity Imaging Laboratory, led by Elisa Konofagou, Robert and Margaret Hariri Professor of Biomedical Engineering, develops novel, ultrasound-based techniques for both imaging and therapeutic applications.
and tau loads—the two hallmark Alzheimer's proteins—while also improving working memory.
The researchers were able to apply this focused ultrasound technique to Alzheimer's patients in a clinical trial and found that there was also a modest beta amyloid reduction in the region of the BBB opening relative to the untreated contralateral brain region.Taken together, these two papers show that focused ultrasound can facilitate the treatment of Alzheimer's either by enhancing gene-editing delivery and expression or by focused ultrasound immunomodulation.
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