A new map of the network of genetic changes that drive the development of brain tumors has been revealed by UCL researchers. The genetic map, published in Brain, is comparable to a map of the London Underground—where different genetic features responsible for driving brain tumors are like stations connected by tracks.
Identifying effective treatments requires an understanding of the variable—and highly individual—relation between tumor genetics,
, and disease mechanisms. Crucially, because this diversity is due to the interaction between multiple genetic changes in tumor development, it is ideally captured as a network.from a given station to another is best found by analyzing the whole network of stations and tracks, the shortest path from normal to abnormal cells in an individual patient is best found by identifying the whole network of possible genetic changes leading to brain tumor development.
Lead author, Dr. James Ruffle , said,"The treatment of brain tumors is in desperate need of innovation: outcomes have hardly changed over the past 30 years. A critical step is gaining an understanding of tumor genetic diversity, which we show here to be accessible, but only to data and mathematical models of great size and complexity. A radical change of approach is needed, and we now have the computational tools to bring it into reality.
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