Transient Oscillation Dynamics During Sleep Provide a Robust Basis for Electroencephalographic Phenotyping and Biomarker Identification

Danmark Nyheder Nyheder

Transient Oscillation Dynamics During Sleep Provide a Robust Basis for Electroencephalographic Phenotyping and Biomarker Identification
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Individualized fingerprints from sleep brainwaves provide a powerful new tool for understanding disease brighamwomens

Transient oscillatory events in the sleep electroencephalogram represent short-term coordinated network activity. Of particular importance, sleep spindles are transient oscillatory events associated with memory consolidation, which are altered in aging and in several psychiatric and neurodegenerative disorders.

What information can be gained by expanding our view of transient oscillatory events and their dynamics? In this paper, we develop a novel approach to electroencephalographic phenotyping, characterizing a generalized class of transient time-frequency events across a wide frequency range using continuous dynamics. We demonstrate that the complex temporal evolution of transient events during sleep is highly stereotyped when viewed as a function of slow oscillation power and phase .

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