One of the hallmarks of Alzheimer's disease is disruption to the body's circadian rhythm, the internal biological clock that regulates many of our physiological processes.
Reviewed by Lily Ramsey, LLMAug 21 2023 Nearly 80% of people with Alzheimer's experience these issues, including difficulty sleeping and worsening cognitive function at night. However, there are no existing treatments for Alzheimer's that target this aspect of the disease.
For many years, we assumed that the circadian disruptions seen in people with Alzheimer's are a result of neurodegeneration, but we're now learning it may be the other way around -; circadian disruption may be one of the main drivers of Alzheimer's pathology. This makes circadian disruptions a promising target for new Alzheimer's treatments, and our findings provide the proof-of-concept for an easy and accessible way to correct these disruptions.
"Circadian disruptions in Alzheimer's are the leading cause of nursing home placement," said Desplats. "Anything we can do to help patients restore their circadian rhythm will make a huge difference in how we manage Alzheimer's in the clinic and how caregivers help patients manage the disease at home."
The researchers also observed improvements in the mice on a molecular level. In mice fed on a restricted schedule, the researchers found that multiple genes associated with Alzheimer's and neuroinflammation were expressed differently. They also found that the feeding schedule helped reduce the amount of amyloid protein that accumulated in the brain. Amyloid deposits are one of the most well-known features of Alzheimer's disease.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Broncos have one running back return and one break through in loss to 49ersWilliams touched the ball on the Broncos' first four plays as he made return from last season's ACL tear
Læs mere »
Intermittent fasting improves Alzheimer's pathology in mouse modelOne of the hallmarks of Alzheimer's disease is disruption to the body's circadian rhythm, the internal biological clock that regulates many of our physiological processes. Nearly 80% of people with Alzheimer's experience these issues, including difficulty sleeping and worsening cognitive function at night. However, there are no existing treatments for Alzheimer's that target this aspect of the disease.
Læs mere »
Alzheimer's book written by Somerset man to help othersStuart Dollery has written about caring for his parents who suffered with Alzheimer's and dementia.
Læs mere »