The current evidence on the role of the gut microbiome in metabolizing sweeteners and their metabolites.
By Neha MathurAug 24 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nutrients, researchers summarized the current evidence on the role of the gut microbiome in metabolizing sweeteners and their metabolites.
Non-nutritive sweeteners use is increasing in the food industry globally, raising great interest among researchers to evaluate the effect of NNS on a host's gut microbiome and physiological status. Specifically, they examined three natural, steviol glycoside, glycyrrhizin, and neohesperidine dihydrochalcone, and two synthetic sweeteners, saccharin and sucralose, and the role of the gut microbiome in their metabolism.
Neohesperidin dihydrochalcone is a natural sweetener found in citrus fruits. Its metabolism by the gut microbiome is not fully understood. A study in 2014 used isosteviol, derived from steviol glycoside, to create a potential anti-tumor agent. They tested the effect of the sosteviol triazole conjugates on different cancer cell lines and found they had anti-proliferative activities.
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