Decades of research have left knowledge gaps about cells that regulate the immune system LifeAtPurdue
Forkhead box protein 3-expressing regulatory T cells suppress conventional T cells and are essential for immunological tolerance.
the master transcription factor of Tcell differentiation and function. However, only a small fraction of Tcell-associated genes are directly bound by and FOXP3 alone is insufficient to fully specify the Tcell programme, indicating a role for other accessory transcription factors operating upstream, downstream and/or concurrently with FOXP3 to direct Tcells can be at least partially attributed to differential expression of transcription factors that fine-tune their trafficking, survival and functional properties, some of which are niche-specific.
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