The recent progress in investigating the inhibitory impact of nanosponges and antiviral delivery against SARS-CoV-2 StanfordMed nanosponge SARSCoV2 COVID19 coronavirus covid antiviral
By Bhavana KunkalikarAug 1 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in Drug Discovery Today, researchers assessed the potential of nanosponges against severe acute respiratory syndrome coronavirus 2 .
Nanosponges are found as both paracrystalline and crystalline forms, which are assessed based on the reaction or synthesis processes. Crystallization of sponges has been found to improve their drug-loading capacity. While nanosponges are widely studied for their potential for biologically neutralizing activity, only a limited number of studies have reported their applicability as an antiviral delivery agent.
A study has reported a two-step neutralization process derived from a decoy nanosponge used against SARS-CoV-2 infection by neutralizing the virus. Such nanosponges have displayed effective protection of the host cells from SARS-CoV-2 infection by competing with them for viral binding. Another study demonstrated the SARS-CoV-2 neutralizing effect of plasma membrane-ACE2 extracellular vesicles in human ACE2 transgenic mice. The study reported effective blocking activity against authentic viral loads of SARS-CoV-2, thus defending the host cells from SARS-CoV-2 infection-induced lung inflammation. Furthermore, intravenous-injected drugs based on nanosponge systems can also be effective in multivalent capturing of SARS-CoV-2.
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