We went two-for-two on superb games to open the NCAA Tournament and we get two more First Four games tonight. Plus, the World Cup has officially expanded to 104 matches. The Pulse ⤵️
He and his school are missing one thing that befits a powerhouse’s resume, though: a ring.
It’s the one knock on what has otherwise been an impeccable run by head coach Mark Few. This year, Gonzaga started slow, which shook off some of the usual expectations but also drew criticisms. Same old Gonzaga coming up short, right?The Zags are ranked No. 8 in KenPom and are winners in nine of their last 10 games., which ended a 75-game home winning streak. The game proved to be a turning point.then walloped by 24 last weekend in the WCC tournament championship game..
Danmark Seneste Nyt, Danmark Overskrifter
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NCAA Tournament First Four picks: Mississippi State-Pittsburgh, Nevada-ASU and moreIf history is an indication, some of the best games of the NCAA Tournament will happen on Tuesday night. SethDavisHoops makes his First Four picks ⤵️
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Intravenous methylprednisolone pulse therapy and the risk of in-hospital mortality among acute COVID-19 patients: Nationwide clinical cohort study - Critical CareBackground Steroids are widely used to modulate the inflammatory reactions associated with coronavirus disease 2019 (COVID-19); however, the optimal upper limit dose of steroid use for acute COVID-19 care remains unclear and currently available data may suffer from a time-dependent bias of no effectiveness or reversed causation given the desperate situation of treatment during this pandemic. Accordingly, the aim of this study was to elucidate the impact of intravenous pulse therapy with methylprednisolone (500 mg or greater per day) on the risk of in-hospital mortality among patients with COVID-19 by controlling for time-dependent bias. Methods We performed a prospective cohort study with 67,348 hospitalised acute COVID-19 patients at 438 hospitals during 2020–2021 in Japan. The impact of intravenous methylprednisolone pulse therapy on the risk of in-hospital mortality was examined based on hazard ratios (HRs) and 95% confidence intervals (95% CIs), with stratification according to the status of invasive mechanical ventilation (iMV). Time-dependent bias was controlled for in a marginal structural model analysis, with reference to patients without methylprednisolone therapy. Results During the study period, 2400 patients died. In-hospital mortality rates of iMV-free patients without or with methylprednisolone pulse therapy were 2.3% and 19.5%, and the corresponding values for iMV-receiving patients were 24.7% and 28.6%, respectively. The marginal structural model analysis showed that intravenous pulse therapy with methylprednisolone was associated with a lower risk of in-hospital mortality among patients receiving-iMV (HR 0.59; 95% CI 0.52–0.68). In contrast, pulse therapy with methylprednisolone increased the risk of in-hospital mortality among iMV-free patients (HR 3.38; 95% CI 3.02–3.79). The benefits of pulse therapy for iMV-receiving patients were greater than in those treated with intermediate/higher doses (40–250 mg intravenously) of methylprednisolone (HR 0.8
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The Pulse: Brackets, brackets, bracketsStart every morning with The Pulse in your inbox. Sign up here. Good morning! We’re going full bracket today, save for a few intermissions. There are two types of bracket sickos in this world: The One-Shot, the person who has already filled it out by this morning and won’t change it. The Editor, the person who has filled it out and made changes twice already. Five more updates will be made this week, the last one coming 10 minutes before tipoff. The point is we’re all bracket fiends, and we’ve officially entered the best part of the year. Welcome back to the shared experience of...
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Check State Pension forecast online for exact weekly payments and any gapsA deadline has been extended allowing people more time to boost their retirement pot.
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Women in Berlin allowed to go topless in swimming pools, says state governmentPeople who want to go swimming in the German capital will soon be permitted to do so without covering their torsos following a discrimination complaint.
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scEvoNet: a gradient boosting-based method for prediction of cell state evolution - BMC BioinformaticsBackground Exploring the function or the developmental history of cells in various organisms provides insights into a given cell type's core molecular characteristics and putative evolutionary mechanisms. Numerous computational methods now exist for analyzing single-cell data and identifying cell states. These methods mostly rely on the expression of genes considered as markers for a given cell state. Yet, there is a lack of scRNA-seq computational tools to study the evolution of cell states, particularly how cell states change their molecular profiles. This can include novel gene activation or the novel deployment of programs already existing in other cell types, known as co-option. Results Here we present scEvoNet, a Python tool for predicting cell type evolution in cross-species or cancer-related scRNA-seq datasets. ScEvoNet builds the confusion matrix of cell states and a bipartite network connecting genes and cell states. It allows a user to obtain a set of genes shared by the characteristic signature of two cell states even between distantly-related datasets. These genes can be used as indicators of either evolutionary divergence or co-option occurring during organism or tumor evolution. Our results on cancer and developmental datasets indicate that scEvoNet is a helpful tool for the initial screening of such genes as well as for measuring cell state similarities. Conclusion The scEvoNet package is implemented in Python and is freely available from https://github.com/monsoro/scEvoNet . Utilizing this framework and exploring the continuum of transcriptome states between developmental stages and species will help explain cell state dynamics.
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