The origin of COVID-19: wildlife trade rather than laboratory leak? PNASNews tulanemedical COVID19 coronavirus covid wildlifetrade virus SARSCoV2
By Dr. Chinta SidharthanNov 15 2022Reviewed by Danielle Ellis, B.Sc. A recent opinion piece published in PNAS discussed the sequence of events concerning the coronavirus disease 2019 pandemic to provide evidence against the alleged leak of severe acute respiratory syndrome coronavirus 2 and the Ebola virus from viral research laboratories in Wuhan, China, and West Africa, respectively.
However, the authors presented evidence from the West African Ebola virus outbreak showing that viruses can emerge at locations very far away from their original occurrence site. Similar patterns were seen for SARS-CoV, where the virus emerged in multiple cities in China far away from where the closely related bat progenitor was found.
Absence of evidence of leaks Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today One of the lab leak theories suggested that the SARS-CoV-2 progenitor might have leaked through experimental human cell cultures of animal models or were engineered to enhance the virulence. Theories also suggested that the similarity of SARS-CoV-2 to coronaviruses found in animals such as pangolins and bats were also engineered.
Additionally, wild species such as the white-tailed deer could be potential reservoirs for SARS-CoV-2 even after the virus has stopped circulating in human populations. Previously, SARS-CoV was shown to have infected multiple intermediate hosts, such as raccoon dogs, ferret badgers, and civets, before infecting humans.
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Timing and Trends for Municipal Wastewater, Lab-Confirmed Case, and Syndromic Case Surveillance of COVID-19 in Raleigh, North CarolinaObjectives. To compare 4 COVID-19 surveillance metrics in a major metropolitan area. Methods. We analyzed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater influent and primary solids in Raleigh, North Carolina, from April 10 through December 13, 2020. We compared wastewater results with lab-confirmed COVID-19 cases and syndromic COVID-like illness (CLI) cases to answer 3 questions: (1) Did they correlate? (2) What was the temporal alignment of the different surveillance systems? (3) Did periods of significant change (i.e., trends) align? Results. In the Raleigh sewershed, wastewater influent, wastewater primary solids, lab-confirmed cases, and CLI were strongly or moderately correlated. Trends in lab-confirmed cases and wastewater influent were observed earlier, followed by CLI and, lastly, wastewater primary solids. All 4 metrics showed sustained increases in COVID-19 in June, July, and November 2020 and sustained decreases in August and September 2020. Conclusions. In a major metropolitan area in 2020, the timing of and trends in municipal wastewater, lab-confirmed case, and syndromic case surveillance of COVID-19 were in general agreement. Public Health Implications. Our results provide evidence for investment in SARS-CoV-2 wastewater and CLI surveillance to complement information provided through lab-confirmed cases. (Am J Public Health. Published online ahead of print November 10, 2022:e1–e11. https://doi.org/10.2105/AJPH.2022.307108)
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Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study - Nature CommunicationsBoth acute and chronic COVID-19 disease (also known as long-COVID) may affect the central nervous system. Here authors characterize the immunological profile of peripheral blood and cerebrospinal fluid of COVID-19 patients in order to identify the main factors that contribute to neurological impairment and the severity of neurological symptoms in Sars-CoV-2 infection.
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Department for Education shows Lancashire secondary school pupils fell further behind their classmates during CovidDisadvantaged secondary school pupils in Lancashire fell further behind their classmates during the pandemic, new figures have shown.
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Lancs firms falsely claimed Covid-19 support loans - and never repaid a pennyTwo firms from Preston and Great Harwood wrongly claimed a combined £97,500
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Have I dodged Covid and what does it mean?Why have some people never had Covid and can that lead to better vaccines?
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