Study evaluated associations between gut microbiome (MB), deoxyribonucleic acid (DNA) methylation (DNAme), and nutrition.
By Pooja Toshniwal PahariaAug 21 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nutrients, researchers evaluated associations between gut microbiome , deoxyribonucleic acid methylation , and nutrition before and during a one-year behavioral weight reduction intervention.
Lifestyle interventions may regulate the genetic activity for phenotype improvements during obesity treatments. The gut microbiome mediates inflammation, appetite regulation, and energy balance. The EPIC array assessed Fecal microbiomes by 16S ribosomal ribonucleic acid sequencing and DNA methylation in whole blood.
Sensitivity analyses were performed by using 82,889 CpG sites within genes which were mapped to the Kyoto Encyclopedia of Genes and Genomes biological pathways involved in metabolism , organ systems , and diseases , considered linked to obesity. At baseline, Ruminiclostridium, was positively related to DNA methylation of the genes 5-Nucleotidase Ecto , Collagen Type XX Alpha 1 Chain , and Collagen Type XVIII Alpha 1 Chain .
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