The effects of oxidative stress on women’s fertility antioxidants_OA fertility womenshealth health stress oxidativestress
By Dr. Priyom Bose, Ph.D.Aug 1 2023Reviewed by Benedette Cuffari, M.Sc. Millions of women throughout the world struggle with infertility. Oxidative stress plays a vital role in the pathophysiology of female infertility.
Previous studies have shown that an exhausted antioxidant system negatively affects the female genital tract. OS damages oocytes and follicles in the female reproductive system, thereby disrupting implantation, damaging the endometrium, and affecting endocrine function. Related StoriesMaternal age plays a significant role in female infertility. By the age of 44, women experience reduced estrogen levels, thus implying reduced protection against oxidative damage to the endometrium.
The underlying mechanisms that link obesity with female infertility are complex and multifactorial. Some mechanisms that have been implicated in this relationship include insulin resistance, inflammation, and alterations in adipokine secretion. Malnutrition also affects female reproduction, as malnourished women are more likely to have impaired endothelium-dependent vasodilation, which induces OS.
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