Shock Coronation Street story that ended in the death of its greatest ever villain
This week, it was announced that the tram involved in the death one of Corrie's most notorious villains had been saved from the scrapheap.
After their relationship begins, Alan has his doubts and starts seeing her friend and Rovers Return barmaid, Gloria Todd behind her back. Learning that the Street's troublemaker Terry Duckworth had been pestering Gloria - the two had previously dated - Alan warns him to stay away. Returning to the screen in January 1987, Alan was confronted with the news that his daughter had been in a crash in Rita's car. Learning that Jenny had been dating her schoolmate, Martin Platt , Alan aggressively confronts him but was persuaded not to hit him when Jenny confesses she was the one driving Rita's car, which they had taken without her permission.
Still with Rita, who supported him through a turbulent period with daughter Jenny following her failed marriage, in 1988, Alan later finds a job fitting burglar alarms. Wanting to go into partnership with his boss, he convinces Rita to loan him £6,000 to buy into the business. View gallery Things go from bad to worse for Alan when his business collapses, with both the bank and Carole - who he was now dating - refusing him a loan. Miraculously, after leaving Carole, he was able to worm his way back into Rita's life and move back in with her and his daughter Jenny.
Hit with repeated rejections from Dawn, he attempts to rape her but she manages to escape by running into the street. This abominable act turned out to be Alan's downfall, as Dawn not only told Rita about the attempted rape but also about his fraudulent business practices. In October 1989, Alan pleads guilty to his crimes at his trial in a bid to avoid prison. He was sentenced to two years in jail, but due to the time he had already spent on remand, was free to walk the cobbles once again.
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Higher blood pressure versus normotension targets to prevent acute kidney injury: a systematic review and meta-regression of randomized controlled trials - Critical CareBackground Renal hypoperfusion is one of the most common causes of acute kidney injury (AKI), especially in shock and perioperative patients. An optimal blood pressure (BP) target to prevent AKI remains undetermined. We conducted a systematic review and meta-analysis of available randomized clinical trial (RCT) results to address this knowledge gap. Methods From inception to May 13, 2022, we searched Ovid Medline, EMBASE, Cochrane Library, SCOPUS, clinicaltrials.gov, and WHO ICTRP for RCTs comparing higher BP target versus normotension in hemodynamically unstable patients (shock, post-cardiac arrest, or surgery patients). The outcomes of interest were post-intervention AKI rate and renal replacement therapy (RRT) rate. Two investigators independently screened the citations and reviewed the full texts for eligible studies according to a predefined form. Results Twelve trials were included, enrolling a total of 5759 participants, with shock, non-cardiac, and cardiac surgery patients accounting for 3282 (57.0%), 1687 (29.3%) and 790 (13.7%) patients, respectively. Compared to lower mean arterial blood pressure (MAP) targets that served as normotension, targeting higher MAP had no significant effect on AKI rates in shock (RR [95% CI] = 1.10 [0.93, 1.29]), in cardiac-surgery (RR [95% CI] = 0.87 [0.73, 1.03]) and non-cardiac surgery patients (RR [95% CI] = 1.25 [0.98, 1.60]) using random-effects meta-analyses. In shock patients with premorbid hypertension, however, targeting MAP above 70 mmHg resulted in significantly lower RRT risks, RR [95%CI] = 1.20 [1.03, 1.41], p | 0.05. Conclusions Targeting a higher MAP in shock or perioperative patients may not be superior to normotension, except in shock patients with premorbid hypertension. Further studies are needed to assess the effects of a high MAP target to preventing AKI in hypertensive patients across common settings of hemodynamic instability. Trial registration This systematic review has been registered on PROSPERO ( CR
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