Targeting chronic endometritis: study reveals potential diagnostic markers FrontMedicine endometritis womenshealths chronic markers diagnostics
By Vijay Kumar MalesuJul 25 2023Reviewed by Lily Ramsey, LLM In a recent study published in Frontiers in Medicine, researchers investigated the gene expression signatures and immune cell involvement in chronic endometritis for potential diagnostic markers and insights into its pathophysiology.
CE is histologically characterized by plasma cell infiltration in the endometrial stroma. A reliable clinical test, clusters of differentiation 138 immunohistochemistry staining, is used in addition to regular histological examination for diagnosis. For the ribonucleic acid sequencing analysis, the researchers randomly selected a subset of patients from the CE and non-CE groups. They ensured that at least 30 patients were in each group for better statistical analysis.
Additionally, quantitative reverse-transcription polymerase chain reaction was used to validate the expression of a specific gene, trans-Golgi network vesicle protein 23 , which may have potential implications in CE. RNA sequencing analysis performed on endometrial tissues from 33 CE and 24 non-CE patients resulted in 20 million read pairs. Differential gene expression analysis identified 20 upregulated genes in the CE group, predominantly related to immunoglobulins, and one consistently elevated gene, TVP23A, in CE samples.
The findings also reported the identification of the TVP23A gene as a novel CE-specific marker. Unlike other genes identified, TVP23A was consistently upregulated in most CE cases, irrespective of the number of CD138-positive cells. This gene's potential role in CE pathophysiology and its specificity makes it a promising candidate for diagnostic markers.
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