Study suggests psychosocial factors, not acute infections, contribute to long-COVID in young adults COVID PASC PCC LongCOVID psychosocial psychosomatic JAMANetworkOpen
By Dr. Chinta SidharthanApr 4 2023Reviewed by Lily Ramsey, LLM In a recent study published in the journal JAMA Network Open, a team of researchers investigated the prevalence of post-coronavirus disease 2019 condition , also known as long-COVID, in adolescents and young adults who experienced acute severe acute respiratory syndrome coronavirus 2 but were not hospitalized.
Various prospective cohort studies have also reported the occurrence of post-infective fatigue syndrome after infections with giardiasis, mononucleosis, and fever, where patients experience persistent symptoms such as fatigue causing severe disability despite clinical examination findings being scarce.
The participants were followed-up at six and 12 months. During the study period, the Alpha variant of SARS-CoV-2 was dominant in the geographical area where the study was conducted. Antibodies against the SARS-CoV-2 nucleocapsid protein and spike protein receptor binding domain and Epstein-Barr virus were also assayed to detect previous infections.
Results The findings indicated that although the prevalence of PCC at six months among adolescents and young adults who had suffered from COVID-19 but had not been hospitalized was 48.5%, the prevalence of PCC was also found to be high in the control group consisting of individuals who tested negative for SARS-CoV-2.
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