In 2007, the teams of Massimo Terzolo and Martin Fassnacht published a study in the New England Journal of Medicine that provided evidence for the efficacy of mitotane in the prevention of recurrence in adrenocortical carcinoma. This study established the drug worldwide as a standard therapy for relapse prophylaxis after surgical removal of the tumor, regardless of risk factors that were still unknown at the time.
Adrenocortical carcinoma is a malignant degeneration of one of the hormone glands, which sit in pairs as small caps on the kidney. Credit: Nuclear Medicine University Hospital WürzburgNew England Journal of Medicine
The 5-year RFS rate was 79% in the mitotane group and 75% in the surveillance group. The 5-year overall survival rate was not statistically significantly different. However, all study participants who received mitotane experienced adverse events, and eight people discontinued treatment. Mitotane treatment can be associated with nausea, diarrhea, dizziness and even speech problems. Patients who did not want to be randomized were followed up in a prospective follow-up study.
Endocrinology at Würzburg University Hospital is considered an international reference center for the diagnosis, treatment and research of adrenocortical carcinoma and is currently the largest center worldwide. The usually highly malignant tumor of this endocrine gland, which sit in pairs on the kidneys, has been the focus of Würzburg endocrinology for more than 20 years.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
EastEnders Cindy Beale spoilers as Michelle Collins returnsCindy was last seen in Walford back in 2007
Læs mere »
New plan to make Lewis's into 'department store of experiences'The iconic Grade II listed site has sat mostly empty since 2007
Læs mere »
ALS and frontotemporal dementia show origins in utero, according to new studyEven though neurodegenerative diseases often strike in middle age or later, patients could have structural differences in their brains that arise before birth.
Læs mere »
Mitochondrial DNA study offers several new findings, reveals confounding factor in previous researchResearchers at the Broad Institute of MIT and Harvard, Cambridge, have interrogated several interconnected questions related to mitochondrial DNA (mtDNA) heteroplasmy and the influence of nuclear genetics.
Læs mere »
Children's well-being worsened over past six years during and after the pandemic, study findsWhile COVID-19 lockdowns are no longer mandated, the stress and anxiety of the pandemic still lingers, especially among young South Australians, say health experts at the University of South Australia.
Læs mere »
Study explores the effects of different diets on plasma proteinsResearchers investigated the relationship between diet and the proteome.
Læs mere »