Study shows consistent efficacy of Paxlovid regardless of age, number of vaccinations, comorbidities Efficacy Coronavirus Disease COVID SARSCoV2 nirmatrelvir ritonavir Paxlovid Ontario medrxivpreprint PublicHealthON UofT MGHToronto MemorialU
In Ontario, Paxlovid has been widely available since April 2022. The therapeutic has received universal funding for all COVID-19 patients residing in community-based settings with authorization for use only in SARS-CoV-2-infected individuals with advanced age, comorbidities, and under-vaccinated.
Using a population-based observational cohort study, researchers evaluated Paxlovid's effectiveness in reducing hospitalizations and deaths from COVID-19, while Omicron and its subvariants are predominant. Paxlovid prescription data, SARS-CoV-2 testing data, and vaccination data were obtained from the ODB , C19INTGR, and COVAXON databases, respectively. Comorbidity data were obtained from the CIHI databases, OHIP database, and other validated disease-specific ICES cohorts. Data analysis was performed at ICES.
Hospitalizations or deaths in the 30 days were lower among Paxlovid-treated patients compared to the unexposed patients [two percent versus four percent, equating to 44% RR , wOR 0.6]. In addition, the relative chances of mortality significantly lowered among treated individuals .
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