Study reveals lung vascular differences in growth-restricted fetuses

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Study reveals lung vascular differences in growth-restricted fetuses
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If during a pregnancy a fetus grows below normal thresholds, at each week of gestation there is an increased risk that some of its organs may not develop properly, which can adversely affect the baby's health after birth.

May 17 2024Universitat Pompeu Fabra - Barcelona If during a pregnancy a fetus grows below normal thresholds, at each week of gestation there is an increased risk that some of its organs may not develop properly, which can adversely affect the baby's health after birth. The life-long effects of restricted fetal growth on brain and cardiovascular development have been the subject of much research, but there is a lack of scientific evidence on its impact on the lungs.

The results of the study, recently reported in an article in the journal Scientific Reports , open the door to designing therapies to improve the lung development of fetuses with below-normal growth levels and prevent respiratory health problems, which could extend beyond infancy and into adolescence and adulthood.

More than 200 pregnant women participated in the study This research involved analyzing fetal blood flow circulation and how it is altered when the mother receives extra oxygen, in the fetuses of 208 pregnant women at between 24 and 37 weeks of gestation. All of the women attended Hospital Clínic in Barcelona, where they underwent all the necessary tests for this study. In 97 of these cases, the fetuses had restricted growth, resulting in very low birth weight.

In contrast, the resistance of organs, such as the lungs, cannot be measured directly with ultrasound, and a computer model representing the heart and blood vessels was used to measure it. To draw a parallel, we could compare this computer model to the simulation of an electronic circuit.

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