Study reports the first protein-based diagnostic signature to discriminate MIS-C from Kawasaki Disease and other common infections virus infection disease diganosis LivUni uniofwarwick imperialcollege
By Dr. Liji Thomas, MDAug 4 2023Reviewed by Benedette Cuffari, M.Sc. The coronavirus disease 2019 pandemic was widely understood to spare children, both in terms of the number of infections and severity of disease. Nevertheless, children continue to be infected with the severe acute respiratory syndrome coronavirus 2 , with a significant minority of patients experiencing severe symptoms in the form of multisystem inflammatory syndrome in children .
Introduction While MIS-C is established as a clinical diagnosis, there remains a lack of information on the pathogenesis of this condition. Also known as pediatric inflammatory multisystem syndrome temporally associated with COVID-19 , MIS-C typically arises two to six weeks following SARS-CoV-2 infection in children.
About the study To develop guidelines that will discriminate between these conditions, the researchers of the current study analyzed a set of different plasma proteins to identify those that could be used as biomarkers of MIS-C but not other similar illnesses. Related StoriesUsing these three biomarkers, the researchers successfully distinguished seven out of eight cases of MIS-C from other similar conditions. This combination was optimal for this purpose as compared to the use of any two markers.
CD163, which is a scavenger protein that is found in its soluble form when shed during inflammation, is often raised in SARS-CoV-2 infection in children. Likewise, CD163 levels also rise with macrophage activation, thus corroborating its assigned value as an indicator of critically severe MIS-C.
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