Study presents rare cases of COVID-19-associated pulmonary aspergillosis COVID19 SARSCoV2 Coronavirus PulmonaryAspergillosis
By Neha MathurOct 14 2022Reviewed by Aimee Molineux A recent study published in the Indian Journal of Critical Care Medicine presented a case series of patients with coronavirus disease 2019 -associated pulmonary aspergillosis . The goal of the study was to inform clinicians and healthcare workers of this serious COVID-19-related complication.
Thus, critically ill COVID-19 patients with acute respiratory distress syndrome admitted to intensive care units are prone to developing CAPA. Keeping this in mind and the occurrence of influenza-associated aspergillosis , IPA diagnosis is a must for COVID-19 patients as well. However, it is worth noting that radiology alone cannot always accurately diagnose CAPA in COVID-19 patients.
Study findings High-resolution computed tomography showed cavitary lesions in the lungs of these patients. Although HRCT findings pointed to the possibility of CAPA, they also performed a serum galactomannan test to enhance the diagnosis. Serum galactomannan assay was positive for all the patients. Due to the risk of severe acute respiratory syndrome coronavirus 2 transmission and aerosolization, doctors avoided bronchoscopy.
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Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism - Molecular MedicineBackground Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular transformation biomarkers in Long-COVID patients. Methods A case–control study utilizing Long-COVID patients, one to six months (median 98.5 days) post-infection, with multiplex immunoassay measurement of sixteen blood biomarkers of vascular transformation, including ANG-1, P-SEL, MMP-1, VE-Cad, Syn-1, Endoglin, PECAM-1, VEGF-A, ICAM-1, VLA-4, E-SEL, thrombomodulin, VEGF-R2, VEGF-R3, VCAM-1 and VEGF-D. Results Fourteen vasculature transformation blood biomarkers were significantly elevated in Long-COVID outpatients, versus acutely ill COVID-19 inpatients and healthy controls subjects (P | 0.05). A unique two biomarker profile consisting of ANG-1/P-SEL was developed with machine learning, providing a classification accuracy for Long-COVID status of 96%. Individually, ANG-1 and P-SEL had excellent sensitivity and specificity for Long-COVID status (AUC = 1.00, P | 0.0001; validated in a secondary cohort). Specific to Long-COVID, ANG-1 levels were associated with female sex and a lack of disease interventions at follow-up (P | 0.05). Conclusions Long-COVID patients suffer prolonged, diffuse symptoms and poorer health. Vascular transformation blood biomarkers were significantly elevated in Long-COVID, with angiogenesis markers (ANG-1/P-SEL) providing classification accuracy of 96%. Vascular transformation blood biomarkers hold potential for diagnostics, and modulators of angiogenesis may have therapeutic efficacy.
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