Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates biorxivpreprint Monkeypox MonkeypoxVirus Vaccine
By Pooja Toshniwal PahariaNov 28 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers developed two monkeypox virus quadrivalent messenger ribonucleic acid vaccines, mRNA-A-lipid nanoparticle and mRNA-B-LNP.
About the study In the present study, researchers developed IMV-specific and EEV-specific quadrivalent mRNA-based mRNA-A-LNP vaccine and the mRNA-B-LNP vaccine against MPXV that generated potent immunoglobulin G titers and vaccinia virus -neutralizing antibodies. Modified mRNA sequences were synthesized, capped, and purified. Further, the efficacy and immunogenicity of the two vaccine candidates were evaluated in BALB/c-type mice immunized with the vaccines twice intramuscularly. Subsequently, serum samples were obtained from the mice on day ten and day 24 of their initial immunization for humoral immunity assessments.
Results The vaccine candidates induced potent anti-MPXV IgG titers and anti-VACV neutralizing antibody titers in mice with the generation of durable anti-MPXV killer memory T-lymphocyte and memory B-lymphocyte immune responses in the animals. The passive serological transfer of sera from mice immunized with the two vaccines protected nude mice against VACV. Further, double-dose vaccinations of the two vaccine candidates also protected against VACV in BALB/c mice.
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