Researchers investigated early pathophysiological mechanisms potentially underlying PASC post-SARS-CoV-2 infection.
By Neha MathurSep 4 2023Reviewed by Sophia Coveney In a recent article published in bioRxiv* server, researchers used a preclinical animal model to investigate early pathophysiological mechanisms potentially underlying post-acute sequelae of severe acute respiratory syndrome coronavirus 2 infection , especially its neurological symptoms.
SARS-CoV-2 ribonucleic acid has been found in brain tissues of patients who died due to COVID-19. It has been postulated that brain cells expressing angiotensin-converting enzyme 2 and transmembrane serine protease 2 are an entry route for SARS-CoV-2 invading the central nervous system . The team autopsied the SARS-CoV-2 infected test animals to collect tissue from the pyriform cortex/amygdala and olfactory epithelium for further analysis. The olfactory epithelium may be uniquely prone to SARS-CoV-2 invasion as a result of its neuroanatomical location.
Next, they dual-labeled the tissues derived from the pyriform cortex/amygdala for SARS-CoV-2 mRNA and platelet-derived growth factor receptor beta . The latter is a biomarker exclusively expressed by pericytes in the adult brain. It helped them directly visualize each SARS-CoV-2 mRNA transcript in the brain, represented by a single-dot staining pattern.
They had undetectable viral loads, and no clinical pathology by the end of the experimentation window, i.e., 21-28 days post-infection. These results confirmed that a non-human primate model is apt for studying early pathophysiological changes occurring during PASC post-acute SARS-CoV-2 infection. Notably, they also found SARS-CoV-2 mRNA in the olfactory epithelium but at much lower levels compared to the pyriform cortex/amygdala. These observations further favor the notion that SARS-CoV-2 persists in the CNS.
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