Nearly half of all patients with brain metastasis experience cognitive impairment. Until now, it was thought that this was due to the physical presence of the tumor pressing on neural tissue. But this 'mass effect' hypothesis is flawed because there is often no relationship between the size of the tumor and its cognitive impact. Small tumors can cause significant changes, and large tumors can produce mild effects. Why is this?
The metastasis is shown to interact with a neuron . This neuron has been artificially marked for research, but is surrounded by many more, also interacting with the metastasis. Credit: Manuel Valiente. CNIO
These results show that metastasis does indeed affect the brain's electrical activity in a specific way, leaving clear and recognizable signatures." in the basic understanding of the development of brain metastases and has implications for the prevention, early diagnosis and treatment of this pathology.
resulting from tumor-induced biochemical and molecular alterations. This is a paradigm shift that could have important implications for diagnosis and therapeutic strategies."
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