Study finds increased risk of POTS after SARS-CoV-2 infection or COVID vaccination Coronavirus Disease COVID SARSCoV2 tachycardia NatureCVR karolinskainst UBuffalo
By Pooja Toshniwal PahariaDec 20 2022Reviewed by Benedette Cuffari, M.Sc. In a recent News & Views article published in the journal Nature Cardiovascular Research, researchers report the frequencies of novel postural orthostatic tachycardia syndrome -related diagnoses including POTS, fatigue, dysautonomia, Ehlers–Danlos syndrome, and mast cell diseases, prior to and after severe acute respiratory syndrome coronavirus 2 infection and coronavirus disease 2019 vaccination.
POTS is a common autonomic nervous system disorder that is characterized by tachycardia or an increase of 30 beats/minute or more during 10 minutes of being in the standing position and orthostatic intolerance symptoms. POTS symptomatology includes palpitations, pre-syncope, generalized weakness, light-headedness, nausea, and headache that lasts for more than three months.
About the study Electronic health records data from 284,592 COVID-19 vaccinees and 12,460 SARS-CoV-2-positive individuals were analyzed. The sample population of the study comprised 300,000 COVID-19 vaccinees from Los Angeles County in the United States of America. The assimilation of all new-onset POTS-related diagnoses together yielded marginally lower odds. Among SARS-CoV-2-positive individuals, the pre-COVID-19 incidence of new-onset POTS was 2% as compared to 3% post-COVID-19. Thus, the risk of developing POTS was greater among individuals with SARS-CoV-2 infections as compared to those after COVID-19 vaccination.
Nevertheless, the rate of new POTS diagnoses was more than five-fold greater post-COVID-19 as compared to that following vaccinations. This finding underpins the importance of vaccinations and can be referenced by healthcare professionals to reduce COVID-19 vaccine reluctance among the public.
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