Study discovers triple immunotherapy combination as possible treatment for pancreaticcancer naturecancer
"This triple combination therapy led to an unprecedented curative response in our models," said corresponding author Ronald DePinho, M.D., professor of Cancer Biology."The prevailing view has been that pancreatic cancer is impervious to immunotherapy, but thisshows that it can be vulnerable to the right combination therapy.
The researchers used high-dimensional immune profiling and single-cell RNA sequencing to study how the TIME is affected by a variety of immunotherapies. They identified specific immune checkpoint proteins, 41BB and LAG, that were highly expressed in exhausted T cells. The researchers also confirmed these two therapeutic targets are present in human pancreatic cancer samples, with 81% and 93% of patients analyzed having T cells with 41BB and LAG3 expression, respectively.
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