Study aims to understand how SARS-CoV-2 affects the brain long-term LongCOVID Neurology Coronavirus Disease COVID alzassociation
By Dr. Priyom Bose, Ph.D.Sep 28 2022Reviewed by Benedette Cuffari, M.Sc. To date, the coronavirus disease 2019 , which arises due to infection with the severe acute respiratory syndrome coronavirus 2 , has claimed more than 6.5 million lives worldwide. Most individuals infected with SARS-CoV-2 remain asymptomatic or experience mild to moderate symptoms; however, some individuals suffer severe symptoms that necessitate hospitalization.
The risk of developing neuropsychiatric or cognitive complications appears to be independent of the initial severe pulmonary illness caused by COVID-19. However, a recent Translational Research and Clinical Interventions study formulated a method to identify the molecular and systemic factors linking COVID-19 to short- and long-term neurologic illness.
Many countries worldwide, including Argentina, Austria, Australia, Chile, China, Canada, Germany, Greece, India, the Netherlands, the United States, Qatar, Thailand, Germany, the United Kingdom, and Thailand, have participated in the study. The study cohort included male and female study participants aged 50 and older. Previous studies have indicated that most COVID-19 patients who required hospital admission belonged to this age group, making the cohort suitable for assessing how viral infection influences cognitive decline and dementia. For future meta-analysis and other studies, all consortium members have agreed to share data procured using the CNS-SC2 methodology.
Robust evidence supporting the incidence of cognitive impairment after COVID-19 in the form of ADRD or otherwise was not reported. Nevertheless, descriptive observations and, where possible, causal association advanced the understanding of post-COVID-19 neuropsychiatric manifestations.
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