A study in AlzheimersRes finds that memory clinic patients, specifically in pre-dementia stages, showed faster decline in memory during COVID-19 lockdown than before, suggesting that lockdown regulations have a deleterious effect on brain health.
Among the limitations of the current study is that all patients were included in a tertiary memory clinic, which might not give a general representation of memory clinic patients in the Netherlands. However, our mixed sample included SCD, MCI, and dementia patients and thus represents the full cognitive continuum.
Among the strengths of this study is our careful statistical approach, using optimal Mahalanobis distance matching, in which we matched patients during COVID-19 lockdown to historical controls. The outcome of the matching analysis had led to well-balanced groups between lockdown patients and historical controls. In addition, we used standardized cognitive tests to assess longitudinal cognitive decline.
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