Sonica Hans was last seen walking through Bedford town centre, police say.
The sister of a woman who disappeared on Boxing Day 10 years ago said she has "never given up hope".
Bedfordshire Police said it hoped a new appeal would "strike a chord" with the public and lead to further information."Celebrations have never been the same and my sister's presence has always been missed," she said."I will continue to pray she returns to us safely."Sonica Hans is 5ft 3in tall, with long black hair which was dyed dark brown
Det Insp Katherine Rivers, from the force's missing persons investigation team, said: "As we celebrate this festive season, it is important to remember there are families who have lost those who are missing.
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