Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer biorxivpreprint UW AntiviralMolecules Therapeutic Cancer
By Neha MathurOct 4 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* server, researchers evaluated the anti-cancer therapeutic efficacy of two structurally-unrelated small molecules, PAV-617 and PAV-951.
About the study Since both viruses and cancers drive departure from homeostasis, researchers in the present study set out to determine whether previously identified assembly modulators had any therapeutic activity against cancer to propose a novel method for the development of cancer therapeutics.
Notably, the authors identified KAP1/TRIM28 as a common target of both PAV-617 and PAV-951 in mass spectrometry and western blot. Crosslinking experiments showed that KAP1 was present in a complex targeted by PAV-617 under native conditions but was lost upon denaturation. Perhaps, it was a distal component of the PAV-617 target multi-protein complex.
Conclusions The initial CFPSA capsid assembly screen identified novel targets relevant to viruses and cancer. Advancing the structure-activity-relationship of PAV-617 and PAV-951 could further help determine whether the antiviral and anti-cancer targets are identical or not.
Danmark Seneste Nyt, Danmark Overskrifter
Similar News:Du kan også læse nyheder, der ligner denne, som vi har indsamlet fra andre nyhedskilder.
Novel peanut-specific human IgE monoclonal antibodies may uncover new therapeutic targets for peanut allergyA recent Frontiers in Immunology journal study by University of North Carolina at Chapel Hill and Vanderbilt University researchers has created an in vitro system to determine potential therapeutics targeting sensitized effector cells based on human, allergen-specific, Immunoglobulin E (IgE) monoclonal antibodies (mAbs).
Læs mere »
Nursing home study shows 4th COVID mRNA dose provides extra protection against severe Omicron outcomesNursing home study shows 4th COVID mRNA dose provides extra protection against severe Omicron outcomes Nursing Omicron Coronavirus Disease COVID medrxivpreprint PublicHealthON UofT McMasterU UHN medrxivpreprint
Læs mere »
Blonde contributes to anti-abortion propaganda, says Planned ParenthoodBacklash against the Marilyn Monroe biopic continues.
Læs mere »