A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk -; 451 in all -; through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.
Nov 9 2023Keck School of Medicine of USC The research, led by the USC Center for Genetic Epidemiology, the Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center, and in the United Kingdom by The Institute of Cancer Research, London, included major increases in representation among men from racial and ethnic groups that have often been left out of such research, revising what is known about genetic risk for the disease.
We're not going to learn everything there is to know about the genetics of prostate cancer by studying only white men. Larger and larger studies, engaging a broader spectrum of populations, are important if we're going to identify genetic markers of risk and develop risk prediction tools that are equally effective across populations."
Haiman and his colleagues found 187 new genetic variants associated with prostate cancer risk. They also found 150 genetic variants from earlier research that were replaced by variants in nearby spots on the DNA double helix that better correlated with prostate cancer risk through the lens of the larger, more diverse sample.
Related StoriesBecause many prostate cancer cases diagnosed today might never reach the point where they are life-threatening -; leading to unnecessary treatment that can degrade quality of life -; differentiating between risk for aggressive disease is key. Up until now, the scientists' system for calculating risk scores has correlated with likelihood of developing prostate cancer, but lacked predictive value about how serious a given case may be.
Prostate Cancer Genetic Variants Whole-Genome Analysis Risk Factors
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