Now, scientists at The Wistar Institute have discovered a potential target for gastric cancers associated with Epstein-Barr Virus; study results were published in the journal mBio.
Reviewed by Danielle Ellis, B.Sc.Aug 22 2023 In the paper, Wistar's Tempera lab investigates the epigenetic characteristics of gastric cancer associated with the Epstein-Barr Virus: EBVaGC. In evaluating EBVaGC's epigenetics -; the series of biological signals associated with the genome that determines whether a given gene is expressed -; the Tempera lab highlights a target that could advance as a future treatment for this type of cancer.
"What we have identified is essentially a self-destruct button within this kind of cancer, and our paper shows that we figured out how to press that self-destruct button," said Tempera. "Normally, a latent virus that reactivates and starts to kill cells is a bad thing.
In EBVaGC, the cancer cells' DNA is hypermethylated: the DNA contains a high percentage of cytosine with a 5-methyl group attached to it . As a silencer of gene expression, DNA methylation allows EBV to remain latent. This methylation pattern plays a significant role in regulating the EBV latency-lysis cycle within the cancer cells.
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