Scientists develop preclinical model of scrub typhus disease Preclinical AnimalModel ScrubTyphus BushTyphus Orientia tsutsugamushi PLOS utmbhealth
Study: Host transcriptomic profiling of CD-1 outbred mice with severe clinical outcomes following infection with Orientia tsutsugamushi. Image Credit: Anestial / Shutterstock
The infection is primarily self-limiting with minor symptoms, including skin lesions, fever, and other flu-like symptoms. However, in severe cases, patients can develop pneumonia, liver inflammation, and meningoencephalitis, which may result in severe tissue damage, multiorgan failure, and even death.
Previous studies investigating Orientia tsutsugamushi infection have used inbred mouse models. However, these models are not suitable for studying the impact of genetic diversity on the clinical course of Orientia tsutsugamushi infection. Pathological changes in Orientia tsutsugamushi infection Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today The outbred mice infected with Orientia tsutsugamushi developed pulmonary edema, interstitial pneumonia, perivascular lymphocytic infiltrates, and vasculitis, which are the primary pathological features of severe Orientia tsutsugamushi infection observed in humans.
Immune response to Orientia tsutsugamushi infection The lung immune response to Orientia tsutsugamushi infection was assessed in the study by performing a differential analysis of 562 immunology-related genes in lung tissues. Overall, these observations indicate that macrophage-inducible C-type lectin , an innate immune receptor, plays a vital role in sensing Orientia tsutsugamushi infection and stimulating type 1 cytokines and chemokines.
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