Risks of stroke, its subtypes and atrial fibrillation associated with glucagon-like peptide 1 receptor agonists versus sodium-glucose cotransporter 2 inhibitors: a real-world population-based cohort study in Hong Kong - Cardiovascular Diabetology

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Risks of stroke, its subtypes and atrial fibrillation associated with glucagon-like peptide 1 receptor agonists versus sodium-glucose cotransporter 2 inhibitors: a real-world population-based cohort study in Hong Kong - Cardiovascular Diabetology
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A study in Cardiovascular Diabetology finds that glucagon-like peptide-1 receptor agonists use is associated with lower risk of ischemic stroke and may be the preferred agent for patients with type 2 diabetes at risk of ischemic stroke.

]. Comorbidities are also recorded by clinicians as diagnosis codes of International Classification of Primary Care, second edition or the International Classification of Diseases, Ninth Revision, Clinical Modification when patients attend any clinic visits or are hospitalized. The use of medications refers to the dispensing records under the Hospital Authority when patients attend any clinic visits or are hospitalized.

After applying the inclusion and exclusion criteria, a total of 38,543 eligible patients were identified and assigned to SGLT2i and GLP-1RA groups.The primary outcome was all events of stroke, consisting of hemorrhagic and ischemic stroke. Secondary outcomes included hemorrhagic stroke, ischemic stroke, incident AF, and cardioembolic stroke.

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