Revolutionizing Drug Design with Light-Activated Tiny Machines RiceUniversity
In a recent study published in Nature Nanotechnology, researchers from Rice University revealed a potent new method for directing cellular activity by using light-activated molecular machines to create intercellular calcium wave signals.
Many of the body’s key muscles are not under conscious control in humans: Smooth muscle tissue lines the veins and arteries, managing blood pressure and circulation; smooth muscle lines the lungs and intestines, and is involved in digesting and breathing. The molecular machines, activated by quarter-second light pulses, allowed scientists to manipulate calcium signaling in a cardiac myocyte cell culture, forcing the quiescent cells to ignite.
Tour added, “A lot of people who are paralyzed have huge digestive problems. It would be a big deal if you could alleviate these issues by causing those relevant muscles to fire without any kind of chemical intervention.” The type and strength of the mechanical stimulation affected the cellular response: In contrast to slower rates and multidirectional rotation, fast, unidirectionally revolving molecular machines produced intercellular calcium wave signals.Tour further stated, “This is mechanical action at the molecular scale.
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