Reversing paralysis with electrical stimulation of neurons Neurons Paralysis spinalcord Nature EPFL NINDSnews
The lumbar spinal cord contains the neurons that regulate the activity of walking. To activate these neurons responsible for walking, the brain transmits orders through descending pathways from the brainstem. An acute spinal cord injury disperses this structured communication system. Although the injury does not cause direct harm to the lumbar spinal cord neurons, the lack of crucial supraspinal commands leaves them dysfunctional. This results in permanent paralysis.
First, the team examined whether EESREHAB could successfully restore walking in a broad population of SCI patients and whether this recovery required remodeling of the lumbar region. Next, the "Stimulation Movement Overground" trial determined the safety and viability of EESREHAB in improving walking recovery in chronic SCI patients.
Body weight support system enabling overground walking and wireless implantable pulse generator operating in closed loop, connected to a paddle lead targeting the dorsal roots that innervate lumbosacral segments. b, Chronophotography showing the transitioning from sitting to walking in a representative participant.
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