By means of CRISPR screening, LMU researchers have provided the first ever comprehensive molecular characterization of T cell infiltration into the central nervous system of people with MS.
Multiple sclerosis is the most common disabling disease of the central nervous system in young adults. The disease is initiated when activated autoreactive T cells infiltrate the CNS and trigger a cascade of tissue injury. The importance of this T cell infiltration is well evidenced from studies in rodent models of the disease and in humans.
Genome-wide in vivo CRISPR screen in rat model The Munich researchers employed a gene editing approach that had not previously been used in connection with MS models. "CRISPR technology raises the possibility of conducting comprehensive and unbiased loss-of-function screens in disease models in vivo," explains Kawakami. Before now, genome-wide CRISPR screens have largely been utilized in investigations relating to cancer pathogenesis, but not yet in relation to MS.
In total, the researchers identified 5 essential inhibitors and 18 essential facilitators of this mechanism.
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Key regulators involved in genesis of multiple sclerosis lesions identifiedBy means of CRISPR screening, LMU researchers have provided the first ever comprehensive molecular characterization of T cell infiltration into the central nervous system of people with MS.
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