Evolution is usually equated with advancement, but the most useful biological innovations aren't always found in the 'highest' organisms.
NGFR increases neuron production even in zebrafish whose brains show signs of Alzheimer's disease, which impedes neurogenesis.trick could also work in mammals with Alzheimer's disease.
New neurons. Activating a gene called NGFR in the brains of Alzheimer's model mice increased the production of new neurons , which may slow the progression of the disease. Credit: Caghan Kizil laboratory, Columbia University Irving Medical Center Mouse brains do not normally express NGFR, but when the researchers activated it in mouse models of Alzheimer's, they found that NGFR stimulated long-term neurogenesis by converting the disease-related physiology of the brain's astrocytes to a healthy and neurogenic state.
The first target, lipocalin-2, is a protein that is elevated in mouse and human brain cells and must be blocked for neurogenesis to proceed."Our findings suggest that if we simply block lipocalin-2's receptor—Slc22a17—we might be able to increase neurogenesis," says Kizil.
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